Zelefsky 2007 — Biochemical Control Nomogram

Zelefsky 2007

Pretreatment Biochemical Control After 3D-CRT/IMRT

Tier A — Exact Public Engine

Citation: Zelefsky MJ, Happersett L, Leibel SA, et al. Pretreatment nomogram predicting ten-year biochemical outcome of three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for prostate cancer. Urology. 2007;70(2):283–287.

Source: Cleveland Clinic RiskCalc (github.com/ClevelandClinicQHS/riskcalc-website) — Exact public engine reproduction.

Endpoints: 5-year and 10-year recurrence-free survival after 3D-CRT or IMRT.

Training cohort: MSKCC definitive RT cohort (3D-CRT and early IMRT era).

Note: This calculator includes restricted cubic spline transformations for PSA, Gleason sum, and RT dose, exactly as published.

Pretreatment Parameters

Pre-treatment PSA (ng/mL) Range: 0.1–50

Clinical T Stage T1A and T1B excluded from model

Biopsy Gleason Score Primary + Secondary grade

Primary Grade

Secondary Grade

Gleason Sum: —

Neoadjuvant Hormonal Therapy

Yes

Total RT Dose (cGy) Range: 6400–8600 (e.g., 7800)

Disclaimer: This calculator is for educational and research purposes only. Results do not constitute medical advice. Always consult with a qualified radiation oncologist for clinical decision-making. Model coefficients are exact reproductions from published literature and the Cleveland Clinic RiskCalc repository.

Pretreatment Parameters

Predicted Biochemical Control